Environment, Farmworker Children, Health & Safety, Pesticides, Research and Studies, Uncategorized

Prenatal Exposure to Organophosphate Pesticides and IQ in 7-Year Old Children

From EHP03.NIEHS.NIH.gov, Environmental Health Perspectives, National Institute for Environmental Health Sciences, National Institutes of Health, Maryse F. Bouchard, Jonathan Chevrier, Kim G. Harley, Katherine Kogut, Michelle Vedar, Norma Calderon, Celina Trujillo, Caroline Johnson, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi, 21 Apr 2011.

Abstract

Context: Organophosphate (OP) pesticides are neurotoxic at high doses. Few studies have examined whether chronic exposure at lower levels could adversely impact children’s cognitive development.

Objective: To examine associations between prenatal and postnatal exposure to OP pesticides and cognitive abilities in school-age children.

Methods: We conducted a birth-cohort study (CHAMACOS) among predominantly Latino farmworker families from an agricultural community in California. We assessed exposure to OP pesticides by measuring dialkyl phosphate (DAP) metabolites in urine collected during pregnancy and from children at age 6 months and 1, 2, 3½ and 5 years. We administered the Wechsler Intelligence Scale for Children-IV to 329 seven-year old children. Analyses were adjusted for maternal education and intelligence, HOME score, and language of cognitive assessment.

Results: Urinary DAP concentrations measured during the 1st and 2nd half of pregnancy had similar relations to cognitive scores, thus we used the average of concentrations measured during pregnancy in further analyses. Averaged maternal DAP concentrations were associated with poorer scores for Working Memory, Processing Speed, Verbal Comprehension, Perceptual Reasoning, and Full Scale IQ. Children in the highest quintile of maternal DAP concentrations had an average deficit of 7.0 IQ-points compared with those in the lowest quintile. However, children’s urinary DAP concentrations were not consistently associated with cognitive scores.

Conclusions: Prenatal but not postnatal urinary DAP concentrations were associated with poorer intellectual development in 7-year-old children. Maternal urinary DAP concentrations in the present study were higher, but nonetheless within the range of levels measured in the general U.S. population.

Citation: Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, et al. 2011. Prenatal Exposure to Organophosphate Pesticides and IQ in 7-Year Old Children. Environ Health Perspect :-. doi:10.1289/ehp.1003185

Received: 08 November 2010
Accepted: 13 April 2011
Online: 21 April 2011

Supplemental Material(44 KB) PDF.

Ahead of Print (AOP)

This EHP Ahead of Print (AOP) article has been peer-reviewed, revised, and accepted for publication. The EHP Ahead of Print (AOP) articles are completely citable using the assigned DOI code for the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

Source: EHP03.NIEHS.NIH.gov, Environmental Health Perspectives, National Institute for Environmental Health Sciences, National Institutes of Health, “Prenatal Exposure to Organophosphate Pesticides and IQ in 7-Year Old Children” by Maryse F. Bouchard, Jonathan Chevrier, Kim G. Harley, Katherine Kogut, Michelle Vedar, Norma Calderon, Celina Trujillo, Caroline Johnson, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi, 21 Apr 2011.

See also: EHP03.NIEHS.NIH.gov, Environmental Health Perspectives, National Institute for Environmental Health Sciences, National Institutes of Health, “Prenatal Exposure to Organophosphates, Paraoxonase 1, and Cognitive Development in Childhood” by Stephanie M. Engel, James Wetmur, Jia Chen, Chenbo Zhu, Dana Boyd Barr, Richard L. Canfield, Mary S. Wolff, 21 Apr 2011.

See also: EHP03.NIEHS.NIH.gov, Environmental Health Perspectives, National Institute for Environmental Health Sciences, National Institutes of Health, “7-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide” by Virginia Rauh, Srikesh Arunajadai, Megan Horton, Frederica Perera, Lori Hoepner, Dana B. Barr, Robin Whyatt, 21 Apr 2011.

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